Oasis PRiME MCX simplifies mixed-mode cation exchange solid phase extraction as the newest member of the Oasis PRiME sample preparation product family. This sample preparation product provides the following benefits: SIMPLER: A defined, generic 3 or 4 Step SPE protocol based on the water wettable Oasis MCX strong cation exchange / reversed-phase sorbent that does not require extensive method development. Allows targeted cleanup of basic compounds.CLEANER: Simpler method removes 99% of phospholipids, a major cause of matrix effects, ion suppression, shorter column lifetimes, increased MS maintenance and higher variability in LC MS quantification. Oasis PRiME MCX is QC’d with this protocol for phospholipid removal.FASTER: Cartridges and plates are designed with a manufacturing optimization to increase flow reproducibility across devices, making processing time more predictable. No conditioning and equilibration steps are required.